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Updated: Aug 6, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Is there any effect of lycopene's preventing peritoneal adhesion formation in rats: an experimental study
Ahmet Bilgi1, Mustafa C Terek2, Gürkan Yiğittürk3
1Department of Gynecology and Obstetrics, Selçuk University Faculty of Medicine, Konya.
Objective:
Effects of lycopene in prevention of intra-abdominal adhesion formation in a rat model.
Methods:
Twenty-eight rats were divided into four groups consisting of 7 rats each. Group 1 (only adhesion), Group 2 (adhesion + corn oil), Group 3 (adhesion + 5 mg/kg lycopene), Group 4 (adhesion + 20 mg/kg lycopene). Adhesion score, histopathology, vascular endothelial growth factor (VEGF) H-score, malondialdehyde (MDA), total antioxidant capacity, and VEGF values were measured.
Results:
There were significantly higher extent, severity, degree, and total adhesion scores in the control and corn-oil group than in the low lycopene and high lycopene group. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When the low lycopene and high lycopene groups were compared in terms of anti-VEGF H-score, no significant difference was observed. Malondialdehyde levels were statistically significantly lower in the control and high lycopene group.
Conclusions:
Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation.
