Related Experiment Video
Updated: Aug 6, 2026

A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
Orthopedic Surgery as a Risk Factor for Extracorporeal Circuit Coagulation in Patients on Hemodialysis: A
Yuki Nakamura1, Arata Osanami2,3, Keitaro Nishizawa2
1Division of Clinical Engineering, Sapporo Medical University Hospital, Sapporo, Japan.
Aim:
This study aimed to investigate the clinical background associated with extracorporeal circuit coagulation (ECC) with a specific focus on the impact of orthopedic surgery.
Methods:
A single-center retrospective observational study of 290 hospitalized adult hemodialysis patients (men/women: 204/86, median age: 70 years) was included. Univariate and multivariate negative binomial regression analyses were performed to identify factors associated with ECC.
Results:
Twenty-five ECC events were observed in a total of 20 (6.8%) patients (men/women: 14/6). In univariate negative binomial regression analysis, orthopedic surgery was significantly associated with ECC (incidence rate ratio, 4.16; 95% confidence interval, 1.68-10.0, p = 0.001). In multivariate analysis, the performance of orthopedic surgery emerged as a potent and independent factor for an increased frequency of ECC.
Conclusion:
Orthopedic surgery is significantly associated with an increased frequency of ECC. This finding highlights the importance of considering orthopedic surgery as a potential clinical factor for ECC in perioperative hemodialysis management.
Related Concept Videos
Hemodialysis II: Procedure and Complications
Hemodialysis I: Introduction
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Peripheral Artery Disease V: Postoperative Nursing Management
Acute Kidney Injury IV: Diagnostic Studies and Prevention