Related Experiment Video
Updated: Aug 6, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
Complement C1q-binding protein at the host-protozoan interface: knowns and unknowns
Sajad Rashidi1, Kurosh Kalantar2, Seppo Meri3
1Molecular Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran; Department of Basic Sciences, Khomein University of Medical Sciences, Khomein, Iran.
Protozoan parasites use Complement C1q-binding protein (C1QBP) for adhesion and immune evasion. Further research is needed to understand C1QBP's role as a signaling hub at the host-parasite interface.
Area of Science:
- Parasitology
- Immunology
- Molecular Biology
Background:
- Protozoan parasites, including Plasmodium and Toxoplasma, utilize host proteins for survival and pathogenesis.
- Complement C1q-binding protein (C1QBP) has been identified as a protein exploited by these parasites.
Purpose of the Study:
- To summarize existing evidence of C1QBP's roles in parasitic infections.
- To highlight knowledge gaps regarding C1QBP's function.
- To propose future research directions for defining C1QBP as a signaling hub at the host-parasite interface.
Main Methods:
- Review of direct experimental evidence.
- Analysis of C1QBP's function in Plasmodium and Toxoplasma models.
Main Results:
- Direct evidence supports C1QBP acting as an adhesion receptor for Plasmodium.
- C1QBP is implicated as a target for immune subversion by Toxoplasma.
Conclusions:
- C1QBP plays multifaceted roles in host-parasite interactions.
- Further investigation is required to elucidate C1QBP's function as a signaling hub.
- Understanding C1QBP's mechanisms can inform therapeutic strategies against parasitic diseases.
More Related Videos
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
13:56A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
Published on: July 18, 2013
Related Concept Videos
Complement System
Allosteric Proteins-ATCase
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...
Diversity of Protists II
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Antibody Actions
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Amebiasis