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Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo
Published on: February 23, 2024
Bioactive Natural Compounds: A Review of Their Integration into Bone Tissue Engineering Scaffolds
Aya N Abd Elwadood1,2, Marwa Y Kenawy3, Doaa A Ghareeb4,5,6
1Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt. aya.nasr1@alexu.edu.eg.
Annals of Biomedical Engineering
|July 21, 2026
Summary
Natural medicinal compounds (NMCs) enhance bone regeneration by improving scaffold bioactivity. Integrating NMCs like curcumin into bone scaffolds shows promise for treating critical-sized defects and promoting healing.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Natural Product Chemistry
Background:
- Bone regeneration is a significant clinical challenge, especially for critical-sized defects.
- Tissue engineering utilizes bioactive natural compounds to enhance bone scaffold efficacy.
- Natural medicinal compounds (NMCs) offer osteoinductive, anti-inflammatory, antioxidant, and antimicrobial properties.
Purpose of the Study:
- To review the integration of NMCs into bone scaffolds for tissue regeneration.
- To assess the potential of NMCs in improving scaffold bioactivity and bone healing.
- To examine fabrication strategies and biological outcomes of NMC-functionalized scaffolds.
Main Methods:
- Review of literature on NMCs (curcumin, resveratrol, berberine, 6-gingerol, allicin) in bone scaffolds.
- Analysis of scaffold fabrication techniques: surface modification, encapsulation, biomimetic mineralization.
- Assessment of in vitro and in vivo studies on functionalized scaffolds.
Main Results:
- NMC-functionalized scaffolds demonstrate enhanced osteogenesis, angiogenesis, and biocompatibility.
- Scaffold fabrication strategies effectively incorporate NMCs, improving biological performance.
- Studies confirm the therapeutic potential of NMCs in bone tissue regeneration.
Conclusions:
- NMCs significantly enhance the bioactivity and regenerative potential of bone scaffolds.
- Nature-inspired bone scaffold designs offer a promising adjunct to conventional therapies.
- Further research into NMC stability, release, and combination therapies is warranted.
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