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Updated: Aug 6, 2026
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Atrial Fibrillation in Patients With Myocardial Infarction: Global Burden, Predictors, and Prognostic Impact
Eddy Xiong1,2,3, Sandhir B Prasad1,2,3, John J Atherton1,2
1Department of Cardiology, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia.
Pacing and Clinical Electrophysiology : PACE
|July 22, 2026
Summary
Atrial fibrillation (AF) significantly increases risks following acute myocardial infarction (AMI). New-onset AF after AMI carries particularly strong negative prognostic implications, necessitating improved risk prediction and tailored therapies.
Area of Science:
- Cardiology
- Arrhythmology
- Acute Myocardial Infarction Research
Background:
- Atrial fibrillation (AF) is the most common sustained arrhythmia globally.
- AF and acute myocardial infarction (AMI) share a complex bidirectional relationship.
- AF increases AMI risk, while AMI can lead to new-onset AF (NOAF).
Purpose of the Study:
- To review the global burden of AF in patients with AMI.
- To explore pre-existing AF and NOAF following AMI.
- To analyze the prognostic impact of AF in the context of AMI.
Main Methods:
- This narrative review synthesizes existing evidence on AF and AMI.
- It covers the prevalence, risk factors, and outcomes of AF in AMI.
- The review examines past, present, and future perspectives.
Main Results:
- Pre-existing AF affects 3-4% of AMI patients, linked to inflammation and thrombosis.
- NOAF complicates 5-20% of AMI cases, with various predictive factors identified.
- AF in AMI patients significantly elevates risks of mortality, stroke, bleeding, and heart failure.
Conclusions:
- NOAF following AMI has particularly strong negative prognostic significance.
- Identifying predictive markers and developing tailored models are crucial.
- Optimizing antithrombotic therapy and patient outcomes in this high-risk group is essential.
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