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From Virtual Modelling to Smarter Endodontic Innovation: In Silico Research for Translational Decision Making
José Evando da Silva-Filho1,2, Eduardo Diogo Gurgel-Filho2
1Department of Dental Radiology and Imaging, University of Fortaleza, Fortaleza, Ceará, Brazil.
International Endodontic Journal
|July 22, 2026
Summary
In silico research offers a powerful computational approach to guide endodontic research, prioritizing hypotheses and experimental conditions before biological validation. This enhances the efficiency and relevance of preclinical investigations in endodontics.
Area of Science:
- Biomedical Engineering
- Computational Biology
- Dental Research
Background:
- Endodontic outcomes are complex, influenced by anatomical, mechanical, chemical, microbial, and host factors.
- Conventional research methods using extracted teeth and standardized tests have limitations in representing clinical variability.
Purpose of the Study:
- To explore the role of in silico research as an early translational decision layer in endodontics.
- To support the prioritization of hypotheses, technologies, and experimental conditions prior to biological and clinical validation.
Main Methods:
- Discusses various in silico approaches: finite element analysis, computational fluid dynamics, probabilistic simulations, molecular modeling, and predictive toxicology.
- Highlights the importance of clearly defined context, justified input data, transparent assumptions, verification, validation, sensitivity analysis, and uncertainty assessment.
Main Results:
- In silico methods can extend preclinical investigations by modeling plausible scenarios across pathological pathways, instrument performance, biomaterials, and irrigation.
- Computational outputs should guide subsequent experimental selection rather than serve as standalone evidence of clinical effectiveness.
Conclusions:
- In silico research acts as a crucial decision layer, optimizing the direction of endodontic research.
- Integrates computational modeling with traditional methods to improve the understanding and treatment of endodontic conditions.
