Related Experiment Video
Updated: Aug 6, 2026
03:38
Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
Functional micro-computed tomography requires baseline characterisation to accurately describe quantitative lung
Davide Buseghin1, Martina Buccardi2,3, Erica Ferrini2
1Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy.
Breathe (Sheffield, England)
|July 22, 2026
Summary
Lung aeration and ventilation in preclinical models differ based on age, sex, and mouse strain. These functional metrics require baseline comparisons for accurate pathological interpretation and quantitative assessment.
Area of Science:
- Physiology
- Preclinical Research
Background:
- Lung function assessment is crucial in preclinical studies.
- Understanding variations in lung aeration and ventilation is key.
Purpose of the Study:
- To investigate age, sex, and strain-specific variations in lung aeration and ventilation.
- To establish the necessity of baseline comparisons for quantitative pathological interpretation.
Main Methods:
- Utilized preclinical functional metrics to assess lung aeration and ventilation.
- Analyzed data across different age groups, sexes, and mouse strains.
Main Results:
- Significant variations in lung aeration and ventilation were observed based on age, sex, and mouse strain.
- Pathological interpretation of these metrics is dependent on changes from baseline.
Conclusions:
- Lung aeration and ventilation exhibit variability influenced by intrinsic biological factors.
- Baseline comparison is essential for the meaningful quantitative assessment of lung function in preclinical studies.
