Research Progress on Animal Models of Chronic Obstructive Pulmonary Disease

Area of Science:

• Pulmonary Medicine
• Animal Models
• Respiratory Disease Research

Background:

• Chronic obstructive pulmonary disease (COPD) presents significant morbidity and mortality.
• Current treatments cannot fully reverse or halt COPD progression.
• Animal models are crucial for understanding COPD pathogenesis and evaluating therapies.

Purpose of the Study:

• To systematically review and compare methods for constructing COPD animal models.
• To identify limitations in existing models for accurately simulating human COPD.
• To provide a reference for researchers and clinicians in selecting appropriate COPD models.

Main Methods:

• Systematic literature review of 5,071 articles from CNKI, PubMed, and Wanfang Database (past decade).
• Analysis of common COPD animal models: cigarette smoke, protease-induced, genetic, harmful substance exposure, and combined factors.
• Comparison of model construction, procedures, pathological features, advantages, and limitations.

Main Results:

• Identified key COPD animal models including smoke exposure, protease-induced, and genetic modifications.
• Highlighted limitations in current models regarding accurate simulation of human COPD clinical symptoms and progression.
• Noted a lack of standardized guidelines and consensus in COPD animal modeling.

Conclusions:

• Existing COPD animal models have limitations in fully replicating human disease.
• Further standardization and consensus are needed for more effective COPD research models.
• This review offers a comprehensive comparison to guide the selection of COPD animal models.