Combination Approach to Hyperpigmentation: Unveiling Enhanced Aesthetic Results With Microneedling and...

To demonstrate the safety and enhanced cosmetic outcomes of the combination of microneedling with a pigment-correcting peel when treating hyperpigmented skin across diverse Fitzpatrick skin types.

A total of 31 patients (Fitzpatrick skin types I-V) with facial hyperpigmentation were enrolled in the study. Each participant received 2 different treatments on the face: 1 side was treated with a pigment-correcting peel combined with microneedling, while the other side received microneedling alone (3 sessions, 4 weeks apart). Assessments included Mexameter measurements, dermatologist grading, and standardized clinical imaging. Self-assessment questionnaires were completed by participants at different timepoints.

The 31 participants completed the study; both microneedling alone and the combination treatment were well tolerated. The combined approach yielded significantly better results according to dermatologist efficacy assessment for clarity/brightness, evenness of skin tone (pigmentation and redness), overall appearance and texture (P<0.05), and patient perception, with 94% reporting a significant or noticeable improvement on skin discoloration/hyperpigmentation on the side treated with combination therapy and 90% reporting they prefer the results of the combination therapy vs microneedling alone (P<0.0001).

A primary limitation of this study was the restricted assessment window, which proved to be insufficient to achieve significant clinical improvement for parameters such as fine lines, wrinkles, and pore size.

This research showed that combining a pigment-correcting peel with microneedling can be significantly more effective at improving overall skin appearance than microneedling alone. This combined therapy was safe, well tolerated, and preferred by participants across a diverse population.