Surgical Outcomes in Fibromatosis: A Single-Centre Outcomes

Area of Science:

• Oncology
• Surgical Pathology
• Fibroblastic Tumors

Background:

• Fibromatosis, a benign yet locally aggressive fibroblastic proliferation, presents management challenges due to high recurrence rates and surgical morbidity.
• Current paradigms lean towards non-operative strategies, but the definitive role of surgery remains under investigation.

Purpose of the Study:

• To evaluate clinical presentation, management strategies, and oncological outcomes for fibromatosis.
• To assess the efficacy of surgical versus non-operative interventions in a single tertiary care center.

Main Methods:

• Retrospective observational study of 33 patients with histologically confirmed fibromatosis from 2006-2021.
• Analysis of patient demographics, tumor characteristics, treatment modalities (surgery, surveillance, systemic therapy), and follow-up data.

Main Results:

• The cohort was predominantly female (81.82%) with a median age of 25 years; lower limb was the most common site.
• Surgery was primary treatment in 75.76% of cases. Progression-free rates were 72% with primary surgery versus 87.5% with non-operative management.
• No significant correlation found between disease-free status and surgical procedure type, margin status, or tumor location.

Conclusions:

• Both surgical and non-operative initial management achieved favorable medium-term disease control for fibromatosis.
• While not statistically significant in this cohort, marginal surgical margins showed a trend towards higher recurrence (50%) compared to wide margins (22%).
• Less radical resection may be viable in selected cases to reduce morbidity, but wider margins are preferable if feasible without functional compromise.