A Geometrically Transient Platform for Bioelectronic Implants

Area of Science:

• Bioelectronic Engineering
• Biomedical Devices
• Materials Science

Background:

• Skin's barrier properties impede direct physiological monitoring without invasive devices.
• Bioelectronic implant design faces challenges in miniaturization for reduced invasiveness and space for integrated electronics.

Purpose of the Study:

• To present a novel, minimally invasive bioelectronic implant with a transient geometry for subcutaneous physiological monitoring.
• To enable multiplexed monitoring of key health markers through a foldable and self-unfolding implantable sensor.

Main Methods:

• Developed a fabrication method using highly flexible substrates for multi-fold miniaturization.
• Designed an implant with transient geometry for insertion and autonomous unfolding post-implantation.
• Validated implantation, operation, and removal through in vitro, ex vivo, and in vivo animal studies.

Main Results:

• Demonstrated successful subcutaneous implantation and autonomous unfolding of the bioelectronic device.
• Successfully monitored physiological markers including pH, temperature, cardiac and respiratory activity, and lithium dynamics.
• Achieved continuous wireless operation and demonstrated proof-of-concept for the entire implantation-to-removal cycle.

Conclusions:

• The developed foldable implantable sensors offer a minimally invasive approach to physiological monitoring.
• This technology facilitates quick, suture-free insertion for multiplexed health monitoring, advancing personalized healthcare.
• The transient geometry design addresses key challenges in bioelectronic implant development for clinical utility.