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Intraosseous Epidermoid Cyst Associated With Impacted Teeth in the Right Mandible
Cuimei Zhang1, Zhijun Hou2, Xuecai Yang2
1Department of Stomatology, New Century Women's and Children's Hospital, Qingdao, Shandong Province, China.
The Journal of Craniofacial Surgery
|July 22, 2026
Summary
Intraosseous epidermoid cysts (IECs) are rare jaw lesions that mimic odontogenic cysts. Definitive diagnosis requires histopathology, but complete excision offers an excellent prognosis.
Area of Science:
- Oral pathology
- Surgical oncology
- Radiology
Background:
- Intraosseous epidermoid cyst (IEC) is a rare benign jaw lesion.
- IECs present diagnostic challenges due to resemblance to odontogenic cysts.
- Definitive diagnosis relies on histopathology, potentially with immunohistochemistry.
Purpose of the Study:
- To present a case of intraosseous epidermoid cyst in the mandible.
- To highlight diagnostic challenges and treatment outcomes.
- To emphasize the role of imaging and histopathology.
Main Methods:
- Case presentation of a 29-year-old female with mandibular cystic lesions.
- Preoperative evaluation using Cone-Beam Computed Tomography (CBCT).
- Complete cyst excision via an intraoral approach followed by histopathologic examination.
Main Results:
- CBCT revealed a well-defined, monolocular, low-density lesion in the right mandible.
- Histopathology confirmed an epidermoid cyst lined by keratinized stratified squamous epithelium.
- No recurrence was noted during postoperative follow-up.
Conclusions:
- Intraosseous epidermoid cysts are rare and often misdiagnosed as odontogenic cysts.
- CBCT aids in assessing lesion extent and relationship with adjacent structures.
- Complete intraoral cystectomy is a safe and effective treatment with a favorable prognosis.
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