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Overcoming Platelet Aggregation Interference: Evaluation of the Complete Blood Count, Differential, and Reticulocyte
Jia-le Gong1, Qing Liao1, Chao-Jun Duan1
1Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The Journal of Applied Laboratory Medicine
|July 22, 2026
Summary
The Mindray BC-6800 Plus analyzer’s complete blood count, differential, and reticulocyte (CDR) mode effectively corrects inaccurate platelet counts caused by aggregation. This technology improves diagnostic accuracy by disaggregating platelets and establishing an objective resampling threshold.
Area of Science:
- Hematology
- Clinical Diagnostics
- Laboratory Automation
Background:
- Platelet aggregation can lead to pseudocytopenias or pseudoneutrophilias, impacting diagnostic accuracy.
- Automated hematology analyzers require robust methods to address platelet count interferences.
Purpose of the Study:
- To evaluate the Mindray BC-6800 Plus analyzer's complete blood count, differential, and reticulocyte (CDR) mode for correcting platelet counts affected by aggregation.
- To determine an objective threshold for resampling based on aggregation severity.
Main Methods:
- Assessed agreement between CDR mode and electrical impedance for platelet counts in normal specimens.
- Evaluated CDR mode's ability to correct false platelet counts due to microcytes/fragments or large platelets.
- Analyzed disaggregation efficacy in aggregated samples and determined the optimal disaggregation threshold using ROC analysis.
Main Results:
- CDR mode showed excellent agreement with electrical impedance for platelet counts in normal samples.
- The CDR mode effectively corrected false platelet count elevations and reductions caused by cellular fragments or large platelets.
- An optimal disaggregation threshold of 162 aggregates was established, with improved prediction accuracy when combined with PLT-OF to PLT-I difference.
Conclusions:
- The CDR channel of the Mindray BC-6800 Plus analyzer effectively corrects spurious platelet counts.
- This technology enhances the reliability of platelet count measurements in the presence of aggregation.
