Related Experiment Video
Updated: Aug 6, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Paraneoplastic Acute Exudative Polymorphous Vitelliform Maculopathy Associated with Early Gastric Carcinoma
Alberto Quarta1,2,3, Rouzbeh Abbasgholizadeh2,3, Ceren Soylu2,3
1Department of Neurosciences, Imaging and Clinical Sciences, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
Retinal Cases & Brief Reports
|July 22, 2026
Summary
This case study highlights a rare association between paraneoplastic acute exudative polymorphous vitelliform maculopathy and early gastric cancer. The vitelliform lesions showed spontaneous regression, eventually leading to outer retinal atrophy without vision loss.
Area of Science:
- Ophthalmology
- Oncology
- Medical Imaging
Background:
- Acute exudative polymorphous vitelliform maculopathy (AEPVM) is a rare condition.
- A potential paraneoplastic association with underlying malignancy is suggested.
Purpose of the Study:
- To report a case of AEPVM presumed to be paraneoplastic.
- To describe the association with early gastric carcinoma.
- To document the natural course including lesion regression and atrophy.
Main Methods:
- A 58-year-old woman with a history of central serous chorioretinopathy presented with visual disturbances.
- Multimodal imaging (SD-OCT, FAF, fluorescein angiography) was performed.
- Systemic evaluation including MRI and endoscopy was conducted to identify malignancy.
Main Results:
- Multifocal vitelliform lesions were observed on OCT.
- An early intramucosal gastric adenocarcinoma was diagnosed and treated.
- Over seven years, lesions regressed with development of localized outer retinal atrophy.
- Visual acuity remained stable at 20/20.
Conclusions:
- AEPVM can be associated with early gastric carcinoma.
- Spontaneous regression of vitelliform lesions may occur, progressing to atrophy.
- Long-term ophthalmological follow-up is crucial for monitoring disease progression.
