Related Experiment Video

Updated: Aug 6, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

SLCO1B1 and MTRR gene variants in pediatric acute lymphoblastic leukemia: a study on Egyptian children

Ali Nabeel Mahdi1, Afaf M Elsaid2, Maha Abdelmoneim Mohammed3

  • 1Biochemistry Division, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.

Molecular Biology Reports
|July 22, 2026
PubMed

Insights

Genetic variations in SLCO1B1 and MTRR are linked to childhood acute lymphoblastic leukemia (ALL) risk in Egyptian children. These findings highlight potential genetic factors influencing ALL susceptibility.

Area of Science:

  • Genetics
  • Oncology
  • Pharmacogenomics

Background:

  • Acute lymphoblastic leukemia (ALL) is a prevalent pediatric cancer affecting white blood cells.
  • The SLCO1B1 gene (encoding OATP1B1) influences drug metabolism, while MTRR is crucial for DNA synthesis and methylation.
  • Genetic variations may impact susceptibility to ALL.

Purpose of the Study:

  • To investigate the association between polymorphisms in SLCO1B1 and MTRR genes and the risk of pediatric ALL.
  • To analyze these genetic variants in an Egyptian population.

Main Methods:

  • Genotyping of SLCO1B1 (rs4149056) and MTRR (rs162036) variants using tetra-primer amplification refractory mutation polymerase chain reaction (T-ARMS-PCR).
  • Study included 100 pediatric ALL patients and 100 healthy controls from Egypt.

Main Results:

  • Significant differences in genotype and allele frequencies were found for both SLCO1B1 (p=0.001) and MTRR (p=0.001, p=0.04) between ALL patients and controls.
  • These results indicate a potential genetic link.

Conclusions:

  • Polymorphisms in SLCO1B1 and MTRR may be associated with susceptibility to pediatric ALL.
  • Further research is warranted to confirm these findings in diverse populations.
Abstract

Keywords:
Acute lymphoblastic leukemiaMethionine synthase reductase genePolymorphismSolute carrier organic anion transporter 1B1

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...