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Familial aggregation in Behçet's Disease: Sibling history as a risk factor for Neuro-Behçet
Emine Büşra Ata1, İbrahim Yahya Çakır2, Asena Eken3
1Department of Internal Medicine, Division of Rheumatology, University of Health Sciences, Gulhane Training and Research Hospital, General Tevfik Sağlam Street, Ankara, 06100, Türkiye. eminebusraata@gmail.com.
Irish Journal of Medical Science
|July 22, 2026
Summary
Having an affected sibling triples the risk of neurological involvement in Behçet's disease (BD). Early recognition of neuro-Behçet is crucial for patients with a family history of BD.
Area of Science:
- Rheumatology
- Neurology
- Genetics
Background:
- Behçet's disease (BD) is a multisystem inflammatory disorder with genetic and environmental influences.
- Understanding familial aggregation's impact is key to pathogenesis.
Purpose of the Study:
- Investigate how a sibling history affects organ involvement and clinical features in Behçet's disease.
- Identify predictors of major organ involvement in BD patients with a family history.
Main Methods:
- Analyzed data from 891 Behçet's disease patients, stratified by family history (n=651) and affected sibling (n=70).
- Retrieved demographic, clinical, and laboratory data.
- Used logistic regression to identify predictors of major organ involvement, adjusting for covariates.
Main Results:
- Patients with an affected sibling showed significantly higher rates of neurological involvement (20% vs. 7.5%).
- A sibling history was associated with a threefold increased risk of neurological involvement (OR: 3.01).
- Demographics and smoking status were similar between groups.
Conclusions:
- An affected sibling increases the risk of neurological involvement in Behçet's disease by threefold.
- Early recognition of neuro-Behçet is critical in individuals with a family history.
- Clinicians should be vigilant for neurological manifestations in BD patients with affected siblings.
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