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Knowledge, attitudes, and practices in pediatric hypoglycemia in Italy (KAPPHy study)

Arianna Maiorana1, Roberta Pajno2, Francesco Tagliaferri3,4

  • 1Division of Metabolic Diseases and Hepatology, Ospedale Pediatrico Bambino Gesù, Rome, Italy.

Journal of Endocrinological Investigation
|July 22, 2026
PubMed

Insights

Pediatric hypoglycemia management in Italy shows variability in diagnostic thresholds and technology use. Harmonized national guidelines are needed for consistent diagnosis and treatment of childhood hypoglycemia.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Diseases
  • Clinical Practice Guidelines

Background:

  • Childhood hypoglycemia presents significant morbidity and potential long-term neurological issues.
  • Current diagnostic and management strategies for pediatric hypoglycemia are inconsistent, especially post-neonatal period.

Purpose of the Study:

  • To assess current diagnostic and therapeutic practices for pediatric hypoglycemia in Italy.
  • To evaluate practices among members of the Italian Society of Pediatric Endocrinology and Diabetology (SIEDP) and the Italian Society of Metabolic Diseases and Newborn Screening (SIMMESN).

Main Methods:

  • An anonymous electronic survey with 43 questions was distributed to SIEDP and SIMMESN members.
  • Descriptive statistics and comparative analyses were performed on the survey data.

Main Results:

  • 118 respondents participated, most with direct experience in pediatric hypoglycemia.
  • Significant heterogeneity was observed in diagnostic thresholds (50, 60, or 70 mg/dL).
  • Differences noted in the use of genetic testing (more by SIMMESN) and continuous glucose monitoring (more by SIEDP).

Conclusions:

  • Pediatric hypoglycemia management in Italy generally aligns with international standards.
  • Variability in diagnostic thresholds, molecular testing, and technology adoption persists.
  • There is a clear need for unified national recommendations and diagnostic definitions.
Abstract

Keywords:
ChildrenHypoglycemiaSIEDPSIMMESNSurvey

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