Related Experiment Video

Updated: Aug 5, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Atrial Dyssynchrony and Bachmann Bundle Pacing: A Review

Jin Un Kim1, Nandita Kaza1, Mohamed Zuhair1

  • 1National Heart and Lung Institute, Imperial College London, London, United Kingdom.

JAMA Cardiology
|July 22, 2026
PubMed

Insights

Atrial dyssynchrony, often overlooked, impairs heart function and increases arrhythmia risk. Bachmann bundle pacing offers a promising strategy to correct abnormal atrial activation and improve cardiac resynchronization.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiac Pacing

Background:

  • Cardiac dyssynchrony affects heart function and clinical outcomes.
  • Ventricular dyssynchrony is treated, but atrial dyssynchrony is underrecognized and untreated.
  • Interatrial dyssynchrony stems from conduction delays or nonphysiological pacing, leading to impaired ventricular filling and arrhythmia risk.

Purpose of the Study:

  • To review the mechanisms and clinical consequences of interatrial dyssynchrony.
  • To evaluate Bachmann bundle pacing as a novel treatment for atrial resynchronization.
  • To discuss its potential as a next step in physiological pacing.

Main Methods:

  • Literature review summarizing current understanding of interatrial dyssynchrony.
  • Evaluation of Bachmann bundle pacing based on emerging data.
  • Discussion of potential benefits and future research directions.

Main Results:

  • Interatrial dyssynchrony is linked to impaired cardiac function and increased atrial arrhythmia risk.
  • Conventional atrial pacing may worsen atrial activation abnormalities.
  • Bachmann bundle pacing may restore physiological atrial activation and improve synchrony.

Conclusions:

  • Bachmann bundle pacing is a potential strategy to correct interatrial dyssynchrony.
  • This approach may improve atrioventricular timing and reduce arrhythmia burden.
  • Further research is needed to optimize implantation and assess clinical impact.
Abstract

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