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Updated: Aug 5, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Cardiovascular Risk Across Different Glomerular Diseases
Luhua Jin1, Jiao Liu, Caoxiang She
1Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney and Urological Diseases, Nanfang Hospital, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Southern Medical University, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology.
Patients with different types of glomerulonephritis have varying cardiovascular risks. Lupus nephritis poses the highest risk, while minimal change disease has the lowest, highlighting heterogeneous cardiovascular outcomes in kidney disease.
Area of Science:
- Nephrology
- Cardiology
- Epidemiology
Background:
- Glomerulonephritis patients face increased cardiovascular risk.
- Impact of specific glomerular disease etiologies on cardiovascular outcomes remains unclear.
Purpose of the Study:
- Compare cardiovascular death risks across distinct glomerulonephritis etiologies.
- Investigate differential cardiovascular outcomes based on glomerular disease type.
Main Methods:
- Analyzed 66,247 patients with 14 glomerulonephritis etiologies from the China Renal Data System (2000-2022).
- Compared risks of cardiovascular death, ischemic heart disease death, and stroke death.
Main Results:
- Immunoglobulin A nephropathy was most common (39%), followed by lupus nephritis (17%).
- Lupus nephritis showed the highest cardiovascular death risk (SMR 27.89), minimal change disease the lowest (SMR 3.91).
- All glomerulonephritis subtypes had higher cardiovascular death risk than the general population.
Conclusions:
- Glomerular diseases present heterogeneous cardiovascular risk profiles.
- Significant variations in cardiovascular risk exist among different glomerulonephritis etiologies.
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