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Updated: Aug 6, 2026
Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Diffusion MRI with a multi-shot rosette readout
Kevin D Harkins1, Tzu-Wei Lee2, Jonathan B Martin3
1Institute of Imaging Science, Vanderbilt University Medical Center, United States of America; Radiology and Radiological Sciences, Vanderbilt University Medical Center, United States of America; Biomedical Engineering, Vanderbilt University, United States of America.
This study shows that rosette readout trajectories effectively correct artifacts in diffusion-weighted imaging (DWI). This technique improves image quality by addressing B0 inhomogeneities, eddy currents, and phase variations in both phantom and in vivo studies.
Area of Science:
- Magnetic Resonance Imaging
- Biomedical Engineering
- Neuroimaging
Background:
- Diffusion-weighted imaging (DWI) is crucial for visualizing microstructural tissue changes.
- Common artifacts in DWI, including B0 inhomogeneities, eddy currents, and phase variations, can degrade image quality and complicate analysis.
- Developing advanced acquisition techniques is essential for robust DWI.
Purpose of the Study:
- To demonstrate the efficacy of a multi-shot rosette readout trajectory for correcting common DWI artifacts.
- To evaluate the performance of rosette DWI at high field strengths (7T and 15.2T).
- To assess the ability of the rosette technique to measure and correct for B0 inhomogeneities, eddy currents, and shot-to-shot phase variations.
Main Methods:
- Multi-shot rosette acquisitions were performed on phantoms and ex vivo ferret brains at 7T.
- Simultaneously, echo-planar imaging (EPI) DWI data were acquired.
- In vivo mouse spinal cords were imaged at 15.2T using both rosette and EPI DWI sequences.
Main Results:
- Rosette DWI demonstrated robust image quality across ex vivo and in vivo samples at both 7T and 15.2T.
- Correction for shot-to-shot phase variations successfully mitigated signal attenuation caused by phase errors.
- The multi-shot rosette acquisition effectively measured and corrected for B0 inhomogeneities, diffusion eddy currents, and phase variations.
Conclusions:
- Multi-shot rosette DWI provides high-quality images and robust artifact correction.
- This technique offers a promising solution for improving the reliability of DWI across various applications and field strengths.
- Rosette readout trajectories represent a significant advancement in mitigating common DWI artifacts.
