Related Experiment Video

Updated: Aug 6, 2026

Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET
10:59

Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET

Published on: August 17, 2022

Mapping the relationship between receptor dynamics and function in G protein-coupled receptors using molecular

Adrián García-Recio1, Alejandro Peralta-García1, Anna Korda1

  • 1Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) & Department of Medicine and Life Sciences at Universitat Pompeu Fabra, Barcelona, Spain.

Current Opinion in Structural Biology
|July 22, 2026
PubMed

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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