Related Experiment Video
Updated: Aug 6, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
Published on: December 3, 2017
Distribution of Total Knee Arthroplasty Periprosthetic Infection Care in the United States: Reported From the
Khaled A Elmenawi1, Isabella Zaniletti2, Hervè Poilvache1
1Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
Background:
There has been growing interest in establishing periprosthetic joint infection (PJI) centers of excellence in the United States (US). However, the current distribution of total knee arthroplasty (TKA) PJI surgeries in the US remains unknown. We aimed to evaluate the surgical volume of institutions and surgeons caring for knee PJI in the US using data from the American Joint Replacement Registry.
Methods:
The American Joint Replacement Registry was utilized to capture all TKAs performed between 2012 and 2022. This resulted in 1,779,422 primary and revision TKAs performed in 1,366 institutions by 8,658 surgeons. Out of these, 45,914 (3%) were for knee PJI (TKA-PJI). We established volume thresholds based on median annual volume groupings to identify high-, medium-, and low-volume surgeons and institutions caring for TKA-PJI. High-volume TKA-PJI threshold for institutions was greater than 40 TKA-PJIs/year, and the high-volume TKA-PJI threshold for surgeons was greater than 11 TKA-PJIs/year. The proportion of surgeries performed by low, medium, and high TKA-PJI volume institutions and surgeons was calculated.
Results:
The median institution annual TKA-PJI volume was four PJIs (range, 1 to 113), and the median surgeon annual TKA-PJI volume was two PJIs (range, 1 to 45). High TKA-PJI-volume institutions and surgeons performed 15 and 10% of the TKA-PJIs, respectively. Only 4% of the TKA-PJIs were cared for by a high-volume TKA-PJI surgeon at a high-volume TKA-PJI institution. In 2022, only 16% of the TKA-PJI surgeries occurred at high TKA-PJI volume institutions, and only 12% were performed by high TKA-PJI volume surgeons.
Conclusion:
In the US, approximately one out of 25 TKA-PJIs were managed by a high-volume TKA-PJI surgeon at a high-volume TKA-PJI institution. These findings raise concern that PJI centers of excellence could restrict access for patients with knee PJI, as a 7-fold expansion in caseload at existing high-volume PJI institutions is not sustainable from a financial, physical, mental, or emotional perspective.
Level Of Evidence:
III (Retrospective).
Related Concept Videos
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...

