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Effect of Testosterone on Asthma Exacerbations
Yash Nayak1, Ekamjit Deol1, Jason M Doherty2
1School of Medicine, Saint Louis University, MO.
Summary
Testosterone therapy (TTh) and androgen deprivation therapy (ADT) in men with asthma did not significantly alter asthma exacerbation rates. These findings are relevant for managing common comorbidities like hypogonadism and prostate cancer.
Area of Science:
- Pulmonary Medicine
- Endocrinology
- Clinical Epidemiology
Background:
- Serum testosterone levels are inversely correlated with asthma prevalence and exacerbations in men.
- The impact of testosterone therapy (TTh) and androgen deprivation therapy (ADT) on asthma exacerbations remains uninvestigated.
Purpose of the Study:
- To investigate the association between TTh or ADT and asthma exacerbations in adult men with asthma.
Main Methods:
- Retrospective study utilizing electronic health records from a tertiary hospital.
- Included adult men with asthma who underwent either TTh or ADT.
- Asthma exacerbation defined as hospitalization for asthma or oral prednisone use for outpatient treatment.
Main Results:
- 229 men received TTh (mean age 60±12) and 93 received ADT (mean age 75±8).
- TTh was associated with similar asthma exacerbation rates before (96.4/1000 patient-years) and during therapy (87.2/1000 patient-years; RR=1.1, p=0.70).
- ADT also showed similar exacerbation rates before (60.4/1000 patient-years) and during therapy (58.3/1000 patient-years; RR=1.0, p=0.50).
Conclusions:
- TTh and ADT in men with asthma are not associated with changes in asthma exacerbation frequency.
- Findings are clinically relevant given the common co-occurrence of hypogonadism, prostate cancer, and asthma.
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