Safety of Messenger RNA COVID-19 Vaccination During Pregnancy: Findings from Post-Vaccination Follow-Up Data from the

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Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes
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Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

Phyumar Soe1, Matthew P Muller2, Jennifer E Isenor3

  • 1Department of Pediatrics, University of British Columbia, Vancouver, BC; Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|July 22, 2026
PubMed

This communication reports post-vaccination follow-up findings from the Canadian National Vaccine Safety Network on COVID-19 vaccination during pregnancy. Among 6606 pregnant participants who received an messenger RNA COVID-19 primary series, 4302 reported their pregnancy status in follow-up surveys. Within 7 months of vaccination, live birth was the most reported outcome, followed by ongoing pregnancy. Our descriptive analysis indicated pregnancy loss among participants vaccinated in the first trimester (8.9%) appeared to be lower than expected and lower than the rates observed both before and during the COVID-19 pandemic. These findings support the safety of messenger RNA COVID-19 vaccination during pregnancy, including early gestation, and current public health recommendations.

Keywords:
COVID-19 vaccinespregnancyvaccine safety

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