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Updated: Aug 6, 2026
06:22
Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
Acute Respiratory Distress Syndrome: Current and Emerging Approaches to Lung Protection
Pedro Leme Silva1, Daniela Nisticò2, Patricia Rieken Macedo Rocco3
1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Bloco G2-042, Ilha do Fundão, 21941-902, Rio de Janeiro, Rio de Janeiro, Brazil.
Clinics in Chest Medicine
|July 22, 2026
Summary
Acute respiratory distress syndrome (ARDS) requires personalized treatment. Tailoring mechanical ventilation to individual patient characteristics and disease phases can improve outcomes and reduce lung injury.
Area of Science:
- Critical Care Medicine
- Pulmonology
- Respiratory Medicine
Background:
- Acute respiratory distress syndrome (ARDS) is a complex lung condition with varied causes and outcomes.
- Current treatments, including lung-protective ventilation, have limitations in improving patient survival.
- A shift towards individualized management strategies is emerging.
Purpose of the Study:
- To explore the potential of precision medicine in managing ARDS.
- To highlight the importance of ARDS subphenotypes and patient-specific factors in treatment decisions.
- To discuss advances enabling personalized mechanical ventilation.
Main Methods:
- Review of current evidence on ARDS heterogeneity and management.
- Analysis of emerging technologies like multiomics and advanced imaging.
- Integration of physiological and biological subphenotyping approaches.
Main Results:
- ARDS is a heterogeneous condition requiring tailored approaches.
- Individualized strategies based on subphenotypes and lung morphology show promise.
- Advances in technology facilitate personalized medicine for ARDS.
Conclusions:
- Personalized mechanical ventilation strategies can improve ARDS outcomes.
- Considering disease phase, lung recruitability, and patient characteristics is crucial.
- Precision medicine offers a path to reduce ventilator-induced lung injury and enhance survival in ARDS.
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