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Chronic GVHD Consortium CATCH Study: Incidence, initial presentation and risk factors for chronic GVHD development

Joseph A Pidala1, Betty K Hamilton2, George Liwei Chen3

  • 1H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States.

Blood Advances
|July 22, 2026
PubMed

Insights

Chronic graft-versus-host disease (GVHD) affects many survivors post-transplant. This study identified early signs and risk factors for chronic GVHD, aiding in early intervention strategies.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Chronic graft-versus-host disease (GVHD) remains a significant complication after allogeneic hematopoietic stem cell transplantation (HCT).
  • Despite declining incidence, up to 30% of survivors develop chronic GVHD, impacting long-term outcomes.
  • Understanding current incidence and early manifestations is crucial for developing effective early treatment strategies.

Purpose of the Study:

  • To determine the current incidence of chronic GVHD and its subtypes after allogeneic HCT.
  • To identify the earliest presenting signs and symptoms of chronic GVHD across various organs.
  • To explore risk predictors and patient-reported outcomes associated with chronic GVHD development and severity.

Main Methods:

  • A prospective, multi-center observational study involving 208 subjects undergoing allogeneic HCT.
  • Regular assessments including clinician evaluations, patient-reported measures (Lee Symptom Score, PROMIS), and biologic sample collection.
  • Data collection occurred pre-HCT, at regular intervals post-HCT, and at the time of chronic GVHD diagnosis.

Main Results:

  • The cumulative incidence of any chronic GVHD was 54% by 24 months post-HCT; 38% required systemic immune suppressive therapy (IST).
  • Commonly affected organs at onset included mouth (42%), eye (41%), and skin (32%), with predominantly mild to moderate severity.
  • Risk factors for requiring IST included baseline donor/recipient CMV positivity, non-PTCY prophylaxis, and changes in specific symptom scores.

Conclusions:

  • Current chronic GVHD incidence remains substantial, with significant organ involvement at presentation.
  • Early detection of specific symptoms and identification of risk factors like CMV status are key for timely intervention.
  • This study provides valuable data for future biomarker research and clinical trials targeting early chronic GVHD therapy.

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