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Updated: Aug 6, 2026
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Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
Non-reproductive tumor progression impairs ovarian function through CXCL10-IL18R1 axis
Shi-Ya Xie1,2,3,4, Shu-Ping Zhang1,2,3,4, Cong-Rong Li1,2,3,4
1Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Experimental & Molecular Medicine
|July 22, 2026
Summary
Non-reproductive tumor progression impairs ovarian function via the CXCL10-IL18R1 axis. Whole cancer cell vaccines reversed this, unlike PD-1 therapy, offering new ovarian protection strategies.
Area of Science:
- Oncology
- Reproductive Biology
- Immunology
Background:
- Tumor progression (TP) can harm adjacent tissues via cytokines.
- The impact of non-reproductive tumor progression (NRTP) on ovarian function remains unclear.
- Ovarian function is susceptible to environmental insults.
Purpose of the Study:
- Investigate how NRTP affects ovarian function.
- Identify mechanisms by which NRTP impairs ovaries.
- Explore therapeutic strategies for ovarian protection against NRTP.
Main Methods:
- Utilized mouse models of fibrosarcoma, colon cancer, and melanoma.
- Administered PD-1 monoclonal antibody and whole cancer cell vaccines (WCV).
- Performed plasma cytokine microarrays and targeted pathway analysis.
Main Results:
- NRTP significantly decreased ovarian function in the M group.
- WCV treatment reversed NRTP-induced ovarian dysfunction; PD-1 therapy did not.
- CXCL10 was identified as a key cytokine, binding IL18R1 to impair ovarian function via fibrosis, follicle overactivation, and inflammation.
Conclusions:
- NRTP impairs ovarian function through the CXCL10-IL18R1 axis.
- WCV shows potential for ovarian protection during NRTP.
- Targeting the CXCL10-IL18R1 pathway offers translational strategies for ovarian protection.
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