Comments on "The Use of Tranexamic Acid in Liposuction for Lipedema: A Retrospective Study on 230 Procedures"

We read with great interest the article on Tranexamic acid use in Liposuction for Lipedema by Bruno and Foti [1]. Evaluating how tranexamic acid affected surgical results and expected blood loss in patients undergoing liposuction for lipedema. The authors provide valuable insights into incidence, prevalence, survival, and diagnostic timelines. However, several methodological considerations merit further discussion. These shortcomings do not undermine the study, but they do suggest the stated treatment effect magnitude may be underestimated. Prospective designs, statistical adjustment for clustering, blinded outcome evaluation, and objective blood loss quantification would all be helpful for future research.No Level Assigned This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .