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Updated: Aug 6, 2026

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
Published on: November 11, 2020
Optimizing inhalation therapy: a computational investigation of ellipsoidal particles in dry powder inhalers
Haniye Abdollahi1, Kaveh Ahookhosh2,3, Malikeh Nabaei1
1Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
Abstract:
Targeted drug delivery seeks to maximize drug deposition in specific respiratory regions while minimizing undesired deposition. This study numerically investigated micron-sized particle deposition in a realistic human tracheobronchial model using an Eulerian-Lagrangian approach. Ellipsoidal particles with a fixed minor axis of 3.6 μm and aspect ratios of 1-10 were analyzed at inhalation flow rates of 30, 60, and 90 L/min. Compared with spherical particles, ellipsoidal particles reduced mouth-throat deposition and enhanced penetration into deeper lungs. At 60 L/min, particles with an aspect ratio of 3 increased deep-lung penetration by 6%, demonstrating their potential for targeted pulmonary drug delivery.
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