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B-cell repopulation and postpartum MS disease activity following ofatumumab cessation for pregnancy in women with
Denisse Bongol1, Maria Antoniou1, Jeremy Chataway1
1Queen Square Multiple Sclerosis Centre, National Hospital for Neurology and Neurosurgery, London, UK.
Background:
Data on ofatumumab use in women with multiple sclerosis (WwMS) planning pregnancy are limited.
Objectives:
We conducted an observational study in WwMS to describe third-trimester CD19 counts, postpartum MS activity and pregnancy outcomes after pausing ofatumumab at conception.
Results:
Twenty-five women were included. Third-trimester CD19 counts remained depleted (median 0.017 × 109/L) in 23 available results. No postpartum relapses occurred (25/25 [100%]), and majority (22/25 [88%]) had no new magnetic resonance imaging (MRI) activity. No new safety signals were identified.
Conclusions:
B-cell depletion persisted into the third trimester following ofatumumab cessation for pregnancy with low postpartum MS activity, although limited by small sample.
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