Comparative Analysis of Choroid Plexus Volume Between MOG Antibody Associated Disease and Multiple Sclerosis

Choroid plexus volume (CPV) has been proposed as a neuro-immunological marker of multiple sclerosis (MS), but its relevance in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remains uncertain. We analyzed CPV in 43 individuals with MOGAD, 48 with MS, and 44 healthy controls using a Bayesian Gaussian mixture modeling applied to 3D-T1-weighted-MRI. Total intracranial volume-normalized CPV did not differ between MOGAD and healthy controls, whereas the MS demonstrated significantly higher values than both groups (p < 0.001) and showed associations with clinical disability. These findings suggest relative preservation of CPV in MOGAD and support a closer association of CPV enlargement with disease-related structural changes in MS than in MOGAD.