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Genetically Predicted Gut Microbiota and Lymphoma Risk: A Mendelian Randomization Study
Danhua Li1, Tongfei Zhou1, Meng Liu2
1Foshan Key Laboratory of Precision Therapy in Oncology and Neurology, Department of Pulmonary Oncology, The First People's Hospital of Foshan (Foshan Hospital affiliated with Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, Guangdong, China.
Current Pharmaceutical Biotechnology
|July 23, 2026
Summary
This study explored gut microbiota's link to lymphoma using genetic data. While preliminary findings suggest potential associations, no definitive causal links were established after rigorous analysis, highlighting the complexity of this relationship.
Area of Science:
- Microbiome research
- Genetics
- Oncology
Background:
- Growing evidence links gut microbiota (GM) to hematological malignancies.
- The specific role of GM in lymphoma pathogenesis remains largely unclear.
- This study investigates potential causal relationships between GM and lymphoma subtypes.
Purpose of the Study:
- To examine the potential causal associations between genetically predicted gut microbial taxa and various lymphoma subtypes.
- To utilize a Mendelian randomization (MR) framework for assessing these relationships.
- To explore potential heterogeneity in GM-lymphoma interactions across different lymphoma entities.
Main Methods:
- Employed bidirectional Mendelian randomization (MR) using genome-wide association study (GWAS) summary data.
- Analyzed data for 211 gut microbial taxa and 10 lymphoma subtypes.
- Conducted sensitivity analyses, reverse MR, Steiger directionality tests, and False Discovery Rate (FDR) correction.
Main Results:
- Identified 22 genera with nominal associations across multiple lymphoma subtypes (e.g., Hodgkin lymphoma, DLBCL, Mantle cell lymphoma).
- Choline showed nominal inverse associations with Diffuse Large B-cell lymphoma (DLBCL) and non-Follicular lymphoma (nFL).
- No associations remained statistically significant after FDR correction, indicating limited robust evidence.
Conclusions:
- Preliminary genetic evidence suggests potential associations between gut microbiota and lymphoma risk.
- Observed heterogeneity across lymphoma subtypes indicates distinct microbiota-lymphoma mechanisms.
- Further research with functional experiments and high-resolution data is needed to confirm biological relevance.
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