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Epigenetic and Non-Epigenetic Functions of EZH2 in Tumor Development: Structural Basis, Signaling Network, and

Yihang Wang1, Chaojiang Fu2, Jinrui Ping1

  • 1School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products and Yunnan College of Modern Biomedical Industry, Kunming Medical University, Kunming, Yunnan, 650500, China.

Current Medicinal Chemistry
|July 23, 2026
PubMed
Summary

Enhancer of Zeste Homolog 2 (EZH2) is a key driver in many cancers. Inhibiting EZH2 shows promise for reactivating tumor suppressor genes and developing new anticancer therapies.

Keywords:
EZH2EZH2 inhibitorsSARanti-cancer effectsepigenetics.methylation mechanism

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