Thromboelastography combined with conventional coagulation parameters for developing a nomogram model to predict...

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Clinical Diagnostics

Background:

• Postpartum hemorrhage (PPH) is a significant cause of maternal morbidity and mortality.
• Accurate prediction of PPH risk is crucial for timely intervention.
• Conventional coagulation parameters may not fully capture the dynamic hemostatic changes in PPH.

Purpose of the Study:

• To develop a quantitative nomogram for predicting PPH risk in parturients.
• To integrate thromboelastography (TEG) with conventional coagulation parameters for enhanced PPH prediction.
• To provide a clinical tool for early detection and management of PPH.

Main Methods:

• Retrospective analysis of 500 parturients' clinical data.
• Comparison of clinical characteristics and coagulation parameters between PPH and non-PPH groups.
• Logistic regression analysis to identify independent risk factors and protective factors for PPH.

Main Results:

• Significant differences observed in history, clinical factors, and coagulation parameters between groups.
• Independent risk factors for PPH included previous cesarean section, prior PPH, anemia, coagulation index (CI), D-dimer (D-D), and antithrombin-III (AT-III).
• Fibrinogen (FIB) was identified as a protective factor against PPH.

Conclusions:

• The developed nomogram integrating TEG and conventional parameters shows excellent predictive accuracy for PPH risk.
• This tool offers improved discrimination and calibration for assessing PPH risk in parturients.
• The nomogram serves as a valuable clinical aid for early PPH intervention.