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Updated: Aug 6, 2026
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
The research landscape and evolutionary trends of platelet-derived extracellular vesicles: a bibliometric and LDA
Liuxin Yu1, Xiaoping Yan2,3, Hongyu Wang1
1Class 2024, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
Introduction:
Since the 2013 Nobel Prize in Physiology or Medicine was awarded, extracellular vesicles(EVs) have made the transition from the laboratory to clinical practice. Platelets, as emerging multifunctional immune cells, have garnered significant attention due to the natural biocompatibility and low immunogenicity of platelet-derived extracellular vesicles (pEVs). However, research in this field currently lacks comprehensive review and analysis.
Methods:
This study utilized the Web of Science database, along with tools such as VOSviewer and CiteSpace, and employed bibliometric analysis and Latent Dirichlet Allocation (LDA) to systematically examine international collaboration, thematic evolution, and research hotspots in this field. In addition, clinical trials related to pEVs were extracted from the PubMed database to assess translational progress.
Results:
Since 2021, the volume of publications in the field of pEVs has remained stable at a high level. The International Journal of Molecular Sciences was the most productive journal. The United States and China were the leading contributing countries, with the United States occupying a central position in global collaboration networks. Harvard Medical School and Eric Boilard were among the most influential institution and author, respectively. Research hotspots have shifted from basic platelet biology and cardiovascular studies toward regenerative medicine and oncology. Clinical trials remain limited and primarily focus on pathophysiological mechanisms, biomarker applications, and therapeutic exploration.
Discussion:
This study provides a comprehensive visualization of the global research landscape and developmental trends in pEVs from 2015 to 2026. Although basic research has expanded rapidly, clinical translation remains limited, indicating a clear gap between laboratory findings and clinical application. Emerging trends highlight increasing attention toward regenerative medicine, oncology, and advanced therapeutic strategies, providing directions for future research.
