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From clinics to discoveries: harnessing national EHR interoperability for research
Josh Lemieux1, Emily R Pfaff2, Richard A Moffitt3
1Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, United States.
Objectives:
To assess whether existing nationwide Health Information Networks (HINs) and Health Information Exchanges (HIEs) can be leveraged for electronic health record (EHR) data acquisition for research-specifically, for the NIH's All of Us Research Program.
Materials And Methods:
The All of Us Center for Linkage and Acquisition of Data (CLAD) collaborated with eHealth Exchange, the nation's largest HIN, to transmit participant-authorized queries to an HIE and a hospital system. Returned FHIR and C-CDA records were mapped to the OMOP Common Data Model and compared with existing All of Us EHR data.
Results:
Newly obtained records provided complementary information, enhancing completeness and research utility.
Discussion:
This pilot demonstrates the feasibility of using HINs/HIEs for patient-authorized data exchange for research. Barriers remain-including inconsistent technical capacity to transact authorizations and data quality variations.
Conclusion:
HINs and HIEs can support secure, patient-authorized EHR exchange for research, offering a pathway to more comprehensive, participant-driven biomedical discovery.
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