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Updated: Aug 6, 2026

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
09:05

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability

Published on: November 21, 2014

Association of Helicobacter pylori infection with the correa cascade: a single-center, retrospective cohort study

Zhangsen Huang1,2, Liang Gu1,2, Yuntao Shi1,2

  • 1Digestive Medicine Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.

Frontiers in Cellular and Infection Microbiology
|July 23, 2026
PubMed

Insights

Helicobacter pylori infection is linked to worsening gastric conditions, including precancerous lesions. Eradicating H. pylori is crucial for preventing disease progression and managing gastric health.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Oncology

Background:

  • Helicobacter pylori (H. pylori) is a key cause of gastric diseases.
  • Limited data exists on H. pylori prevalence across the full spectrum of gastric histopathology in a Chinese cohort.

Purpose of the Study:

  • To investigate H. pylori infection prevalence across Correa cascade stages.
  • To analyze H. pylori's influence on histopathological progression in a longitudinal Chinese cohort.

Main Methods:

  • Retrospective analysis of 13,579 participants undergoing gastroscopy and 14C-Urea Breath Test (UBT).
  • Assessment of gastric mucosa via endoscopic and histopathological findings.
  • Longitudinal analysis using Cox regression to determine disease progression risk.

Main Results:

  • Overall H. pylori prevalence was 62.54%, significantly associated with Correa cascade stages.
  • Prevalence was highest in low-grade intraepithelial neoplasia (77.46%) and lowest in non-atrophic gastritis (61.05%).
  • H. pylori-positive individuals showed higher disease progression rates (9.67% vs. 5.60%) and increased risk (adjusted HR=1.60).

Conclusions:

  • H. pylori infection is significantly associated with advanced gastric lesions and disease progression.
  • Eradication of H. pylori is vital for halting gastric disease advancement.
Abstract

Keywords:
Helicobacter pyloricross-sectional studydisease progressiongastric diseaselongitudinal study

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