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Updated: Aug 6, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
Cardiometabolic reprogramming drives right ventricular dysfunction in pulmonary arterial hypertension: Novel
Saihu Liu1, Mari Okazaki2, Yanling Wu1
1Key Laboratory for Traditional Chinese Korean Medicine Research (State Ethnic Affairs), Key Laboratory of Natural Medicines of the Changbai Mountain (Ministry of Education), College of Pharmacy, Yanbian University, Yanji 133002, China.
Abstract:
With the understanding on right ventricular (RV) dysfunction in pulmonary arterial hypertension (PAH), the perspective innovatively integrates research paradigms on targeting cardiometabolic reprogramming of RV protective therapies to break through the bottleneck of current PAH treatment. The research focuses on three core areas: analyzing and validating metabolic dysregulation in the RV of PAH, exploring cell-specific metabolic dysregulation in the heart of PAH, and probing into the therapeutic strategy for PAH targeting RV metabolism. These aspects aim to deepen the scientific understanding of cardiometabolic reprogramming of RV dysfunction in PAH. This work provides a theoretical foundation and experimental evidence for developing RV-directed therapies that complement existing PAH treatments and improve patient outcomes.
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