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Biofunctionalized Porous POMaC Films Promote Cell Adhesion and Infiltration for Tissue Interfaces
He Sun1,2, Jack Twiddy1,2, Kirstie M K Queener1,2
1Lampe Joint Department of Biomedical Engineering, North Carolina State University and University of North Carolina, Chapel Hill, Raleigh, North Carolina27695, United States.
ACS Applied Bio Materials
|July 23, 2026
Summary
Researchers developed porous poly(octamethylene maleate (anhydride) citrate) (POMaC) films for bioelectronic scaffolds. These soft, bioresorbable materials enhance cell integration and maintain electrical signal transmission for tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Bioelectronics
Background:
- Developing soft, bioresorbable interfaces for bioelectronic scaffolds is crucial for tissue integration and signal transmission.
- Existing materials face challenges in balancing cell interaction and electrical conductivity.
Purpose of the Study:
- To fabricate and evaluate poly(octamethylene maleate (anhydride) citrate) (POMaC) films with varying porosity and surface biofunctionalization.
- To assess the impact of these modifications on cell interactions and electrical signal transmission.
Main Methods:
- Fabrication of planar and porous POMaC films using sacrificial porogens, creating tunable pore architectures.
- Surface biofunctionalization with gelatin, RGD peptide, and laminin.
- Evaluation of cell adhesion, viability, and penetration using human dermal fibroblasts and iPSC-derived cardiomyocytes.
- Electrochemical impedance spectroscopy (EIS) and electrical stimulation to measure signal transmission.
Main Results:
- Porous POMaC films supported robust cell adhesion, viability, and 3D penetration of fibroblasts and cardiomyocytes.
- Surface biofunctionalization, particularly with laminin, enhanced cell adhesion and spreading.
- POMaC films showed preserved ionic coupling with modest impedance changes.
- Porous films demonstrated improved electrical signal preservation compared to non-porous counterparts.
Conclusions:
- Biofunctionalized porous POMaC is a promising bioresorbable interface material for tissue-integrating bioelectronic scaffolds.
- The material supports 3D cell infiltration and maintains electrical signal transmission.
- Further validation in application-specific bioelectronic sensing formats is warranted.
