Related Experiment Video
Updated: Aug 6, 2026
05:34
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
Reproductive Health in CKD and Kidney Failure: Core Curriculum 2026
Saieda A Alleyne1, Ursula C Brewster1, Silvi Shah2
1Section of Nephrology, School of Medicine, Yale University, New Haven, Connecticut.
Summary
Chronic kidney disease (CKD) disrupts reproductive health, causing sexual dysfunction and infertility in men and women. Integrating reproductive counseling into nephrology care is crucial for better outcomes.
Area of Science:
- Nephrology
- Reproductive Endocrinology
Background:
- Chronic kidney disease (CKD) impacts the hypothalamic-pituitary-gonadal axis, affecting sex-hormone balance.
- Increasing CKD incidence in young adults, particularly women of childbearing age, highlights reproductive health concerns.
- Sexual dysfunction and infertility are prevalent but often overlooked in CKD patients.
Purpose of the Study:
- To review the epidemiology, pathophysiology, and management of reproductive health in CKD patients.
- To emphasize the importance of reproductive counseling in nephrology care.
- To address knowledge gaps regarding reproductive issues in CKD, dialysis, and transplantation.
Main Methods:
- Literature review and synthesis of current knowledge on reproductive health in CKD.
- Analysis of epidemiological data and pathophysiological mechanisms.
- Discussion of management strategies across different stages of kidney disease.
Main Results:
- CKD is linked to significant alterations in sex-hormone homeostasis and reproductive function in both sexes.
- Women with CKD face higher risks of adverse pregnancy outcomes.
- Reproductive health issues in CKD are frequently underreported and undertreated.
Conclusions:
- Stage-specific reproductive counseling must be integrated into routine nephrology practice.
- Addressing reproductive health can mitigate adverse maternal, fetal, and kidney outcomes.
- Improved recognition and management are essential for patients with CKD, on dialysis, or post-transplant.
Related Concept Videos
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
01:18Chronic Kidney Disease IV: Nursing Management
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
01:20Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
01:22Acute Kidney Injury VI: Nursing Management
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...