Nocturia is Associated with Biological Age not Chronological Age

Area of Science:

• Gerontology
• Urology
• Biomarkers

Background:

• Nocturia, a common lower urinary tract symptom (LUTS), is often attributed to aging.
• Significant variability exists in nocturia prevalence across age groups, suggesting factors beyond chronological age are involved.

Purpose of the Study:

• To compare the association of chronological age and biological age with nocturnal voiding frequency.
• To investigate whether biological age, assessed by PhenoAge, is a better predictor of nocturia than chronological age.

Main Methods:

• Prospective pilot study of 68 patients undergoing cardiovascular disease evaluation.
• Biological age estimated using PhenoAge, a composite biomarker of systemic aging.
• Nocturnal voiding frequency (number of nighttime voids) recorded.

Main Results:

• Mean biological age (78.8 years) was significantly greater than mean chronological age (70.5 years).
• Biological age (PhenoAge) showed a significant correlation with the number of nighttime voids (r=0.33, p=0.006).
• Chronological age did not significantly correlate with nighttime voids (r=0.084, p=0.49).

Conclusions:

• PhenoAge may be a more relevant measure for understanding nocturia than chronological age alone.
• Biological aging processes, as captured by PhenoAge, appear associated with nocturnal voiding frequency.