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Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
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Towards spatial lipid profiling by using mass spectrometry: analytical challenges and applications

Yaowei Liu1, Yihua Ou1, Hemi Luan2,3

  • 1Department of Biomedical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, Guangdong, China.

Analytical and Bioanalytical Chemistry
|July 23, 2026
PubMed
Summary

Spatial lipidomics uses advanced techniques like mass spectrometry imaging (MSI) to map lipid distribution within tissues. This approach overcomes limitations of traditional methods, enabling new discoveries in disease mechanisms and biomarker identification.

Keywords:
Laser capture microdissectionLipid metabolismMass spectrometry imagingSpatial lipidomicsSpatial multi-omics

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