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A Pure Zwitterionic PSBMA Coating With Ultra-Low Friction, Anti-Adhesion and High Stability for Blood-Contacting
Jiale Cao1,2, Xinzhong Song1,2, Xiangkuan Zhang1,2
1Key Laboratory of High Efficiency and Clean Mechanical Manufacture, School of Mechanical Engineering, Ministry of Education, Shandong University, Jinan, People's Republic of China.
Macromolecular Bioscience
|July 23, 2026
Summary
A novel zwitterionic hydrogel coating significantly improves medical device safety. This poly sulfobetaine methacrylate (PSBMA) coating enhances lubricity and reduces protein and cell adhesion on thermoplastic polyurethane (TPU).
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Engineering
Background:
- Conventional medical device materials face challenges like friction, adhesion, and poor stability.
- Zwitterionic materials offer inherent advantages for blood-contacting applications.
- Improving the surface properties of materials like thermoplastic polyurethane (TPU) is crucial for clinical safety.
Purpose of the Study:
- To develop a robust and stable zwitterionic hydrogel coating for thermoplastic polyurethane (TPU).
- To enhance the surface lubricity, anti-adhesion, and hemocompatibility of TPU for medical devices.
- To investigate a "penetration-crosslinking-entanglement" strategy for creating an integrated coating architecture.
Main Methods:
- Fabrication of a pure poly sulfobetaine methacrylate (PSBMA) zwitterionic hydrogel coating on TPU using a "penetration-crosslinking-entanglement" strategy.
- Covalent bonding and physical entanglement of PSBMA chains with the TPU matrix.
- Characterization of surface properties including hydrophilicity (water contact angle), friction coefficient, and lubrication stability.
- Evaluation of protein adsorption and blood cell adhesion and activation.
Main Results:
- Achieved a robust, integrated coating-substrate architecture with covalent bonding and chain entanglement.
- Created a superhydrophilic surface (water contact angle < 20°) with a significantly reduced friction coefficient (< 0.03).
- Demonstrated stable lubrication under various loads and shear rates.
- Effectively suppressed protein adsorption and blood cell adhesion and activation.
Conclusions:
- The developed PSBMA hydrogel coating offers synergistic improvements in lubricity, anti-adhesion, stability, and hemocompatibility for TPU.
- This simple and scalable strategy provides a promising solution for blood-contacting medical devices, such as interventional catheters.
- The integrated zwitterionic coating enhances the clinical safety and performance of medical device materials.
