The Association Between Triglyceride-Glucose Index and Mortality Risk in Cardiovascular Disease Patients: A...

Area of Science:

• Cardiology
• Metabolic Syndrome
• Epidemiology

Background:

• The triglyceride-glucose (TyG) index is a potential biomarker for cardiovascular disease (CVD) risk.
• Its predictive capacity in CVD patients, especially those without type 2 diabetes mellitus (T2DM), requires further investigation.

Purpose of the Study:

• To evaluate the association between baseline TyG index levels and mortality outcomes in hospitalized CVD patients.
• To examine potential subgroup variations in this association, particularly concerning T2DM status.

Main Methods:

• A systematic literature search was conducted across Embase, PubMed, and Web of Science.
• Seventeen studies with 26,464 participants were included to analyze all-cause and cardiovascular mortality.
• Stratified and sensitivity analyses were performed to assess result robustness.

Main Results:

• Elevated TyG index levels were significantly associated with increased all-cause (HR=1.43) and cardiovascular mortality (HR=1.62) in CVD patients.
• This association was not significant in patients without T2DM.
• A linear dose-response relationship was observed between higher TyG levels and increased all-cause mortality risk.

Conclusions:

• The TyG index may predict mortality risk in CVD patients, particularly in Asian populations.
• Further large-scale studies in diverse ethnic groups are needed to confirm global generalizability.