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Beclin 1 level combined with Gensini score and low-density lipoprotein cholesterol correlate strongly with

Yuting Qu1,2, Ying Xue1, Xiaowei Xiong3

  • 1Beijing University of Chinese Medicine Beijing 100029, China.

American Journal of Translational Research
|July 23, 2026
PubMed

Insights

Serum Beclin 1 levels are significantly decreased in patients with multi-vessel disease (MVD). Lower Beclin 1, combined with Gensini score and LDL-C, effectively predicts MVD risk.

Area of Science:

  • Cardiovascular Research
  • Biochemistry
  • Medical Diagnostics

Background:

  • Coronary heart disease (CHD) diagnosis relies on complex assessments.
  • Identifying reliable biomarkers for disease severity, such as multi-vessel disease (MVD), is crucial.
  • Beclin 1, a protein involved in autophagy, is being investigated for its role in cardiovascular conditions.

Purpose of the Study:

  • To determine the correlation between serum Beclin 1 levels and the presence of MVD.
  • To evaluate the predictive value of Beclin 1, in conjunction with established markers, for MVD.

Main Methods:

  • Retrospective analysis of 169 participants, including 106 with CHD.
  • Categorization into single-vessel disease (SVD) and MVD groups based on coronary angiography.
  • Measurement of serum Beclin 1 using enzyme-linked immunosorbent assay.
  • Statistical analysis including logistic regression and ROC curves.

Main Results:

  • Serum Beclin 1 levels were significantly lower in MVD patients compared to controls and SVD patients.
  • Gensini score was an independent risk factor for MVD.
  • Beclin 1 and LDL-C were identified as independent protective factors against MVD.
  • A combined model (Gensini score + Beclin 1 + LDL-C) demonstrated high predictive accuracy (AUC=0.936) for MVD.

Conclusions:

  • Serum Beclin 1 levels are a significant indicator in patients with coronary heart disease.
  • The combination of Beclin 1, Gensini score, and LDL-C offers robust predictive value for MVD.
  • Beclin 1 may serve as a valuable biomarker for assessing MVD severity.
Abstract

Keywords:
Beclin 1Gensini scoreMulti-vessel disease

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