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Updated: Aug 6, 2026

Synthesis, Hemoglobin Encapsulation and Biorthogonal PEGylation in Hierarchically Porous UiO-66 Nanoparticles for Oxygen Delivery Applications

Synthesis, Hemoglobin Encapsulation and Biorthogonal PEGylation in Hierarchically Porous UiO-66 Nanoparticles for Oxygen Delivery Applications

Published on: May 8, 2026

M-NGO/UiO-66 nanocomposite: a green and efficient catalyst for the synthesis of 1,8-dioxodecahydroacridine

Atefeh Zeinali¹, Leila Moradi¹

¹Department of Organic Chemistry, Faculty of Chemistry, University of Kashan P. O. Box 8731753153 Kashan I.R. Iran l_moradi@kashanu.ac.ir.

|July 23, 2026

Abstract:

In this study, a novel magnetic nanocomposite (M-NGO/UiO-66) was successfully synthesized. This nanocomposite was utilized as a green, heterogeneous, and recoverable catalyst in a one-pot pseudo-four-component reaction for the preparation of 1,8-dioxodecahydroacridine derivatives. The structure and physicochemical properties of the resulting nanocomposite were thoroughly characterized and confirmed using FT-IR, XRD, SEM, EDS, elemental mapping, BET, and VSM techniques. The catalytic performance of M-NGO/UiO-66 was evaluated under optimized reaction conditions, including 0.015 g of catalyst in ethanol at 80 °C, affording the target products within 8-25 min and in high yields ranging from 83% to 95%. The developed protocol demonstrates several significant advantages, such as operational simplicity, excellent catalytic activity, high atom economy, favorable reaction mass efficiency, utilization of a green solvent, and convenient magnetic recovery of the catalyst, making it an attractive and sustainable approach for the synthesis of acridine derivatives.

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