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Cardiac structure and function in patients with inflammatory bowel disease
Yang Yang1,2,3,4,5, Xingyang Luo1,2,3,4, Linxiang Zhou1,2,3
1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Iscience
|July 23, 2026
Summary
Patients with inflammatory bowel disease (IBD) show subtle cardiac changes, including thicker heart walls and reduced ejection fraction. Further research is needed to understand the cardiovascular implications for IBD patients.
Area of Science:
- Cardiology
- Gastroenterology
- Internal Medicine
Background:
- Inflammatory bowel disease (IBD) is linked to heightened cardiovascular risk.
- Quantitative assessment of cardiac structure and function in IBD patients is crucial.
Purpose of the Study:
- To systematically review and meta-analyze cardiac structure and function in patients with IBD compared to healthy controls.
- To identify potential cardiovascular alterations associated with IBD.
Main Methods:
- Systematic review and meta-analysis of 28 studies.
- Inclusion of 1613 patients with IBD and 1303 healthy controls.
- Quantitative comparison of cardiac parameters.
Main Results:
- IBD patients exhibited increased posterior wall thickness (SMD 0.23) and interventricular septum thickness (SMD 0.22).
- Lower ejection fraction (SMD -0.28) and less negative global longitudinal strain (SMD 0.36) were observed in IBD patients.
- Subgroup analyses revealed varied patterns based on disease activity, age of onset, and subtype.
Conclusions:
- Modest differences in cardiac structure and function exist in IBD patients.
- Individual parameter findings require cautious interpretation.
- Standardized prospective studies are necessary for improved cardiovascular assessment and risk stratification in IBD.
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