Related Experiment Video
Updated: Aug 6, 2026
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
Published on: March 1, 2022
Cardiac structure and function in patients with inflammatory bowel disease
Yang Yang1,2,3,4,5, Xingyang Luo1,2,3,4, Linxiang Zhou1,2,3
1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Insights
Patients with inflammatory bowel disease (IBD) show subtle cardiac changes, including thicker heart walls and reduced ejection fraction. Further research is needed to understand the cardiovascular implications for IBD patients.
Area of Science:
- Cardiology
- Gastroenterology
- Internal Medicine
Background:
- Inflammatory bowel disease (IBD) is linked to heightened cardiovascular risk.
- Quantitative assessment of cardiac structure and function in IBD patients is crucial.
Purpose of the Study:
- To systematically review and meta-analyze cardiac structure and function in patients with IBD compared to healthy controls.
- To identify potential cardiovascular alterations associated with IBD.
Main Methods:
- Systematic review and meta-analysis of 28 studies.
- Inclusion of 1613 patients with IBD and 1303 healthy controls.
- Quantitative comparison of cardiac parameters.
Main Results:
- IBD patients exhibited increased posterior wall thickness (SMD 0.23) and interventricular septum thickness (SMD 0.22).
- Lower ejection fraction (SMD -0.28) and less negative global longitudinal strain (SMD 0.36) were observed in IBD patients.
- Subgroup analyses revealed varied patterns based on disease activity, age of onset, and subtype.
Conclusions:
- Modest differences in cardiac structure and function exist in IBD patients.
- Individual parameter findings require cautious interpretation.
- Standardized prospective studies are necessary for improved cardiovascular assessment and risk stratification in IBD.
Abstract:
Inflammatory bowel disease is associated with increased cardiovascular risk, motivating a quantitative assessment of cardiac structure and function in affected patients. We conducted a systematic review and meta-analysis of 28 studies including 1613 patients with inflammatory bowel disease and 1303 healthy controls. Compared with healthy controls, patients showed greater posterior wall thickness (standardized mean difference 0.23, 95% confidence interval 0.12-0.34) and interventricular septum thickness (0.22, 0.05 to 0.39), lower ejection fraction (-0.28, -0.41 to -0.14), and less negative global longitudinal strain (0.36, 0.01 to 0.71). These findings suggest modest differences across cardiac structural and functional domains, although individual parameter-level results require cautious interpretation. Exploratory subgroup analyses showed variable patterns by disease activity, age of onset, and disease subtype. Standardized prospective studies are needed to clarify cardiovascular assessment and risk stratification in inflammatory bowel disease.
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
01:25Inflammatory Bowel Disease III: Crohn's Disease
01:26Inflammatory Bowel Disease I: Introduction
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:20Inflammatory Bowel Disease II: Ulcerative Colitis