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Decoding cardiorenal crosstalk: Intercellular communication mechanisms and therapeutic insights in cardiorenal

Miaomiao Wei1, Yuxiao Cao1, Lei Wei1

  • 1Department of Internal Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300380, China.

Iscience
|July 23, 2026
PubMed

Insights

Cardiorenal syndrome (CRS) involves linked heart and kidney damage. This review explores how cell communication disruptions drive CRS, suggesting new therapies targeting these pathways.

Area of Science:

  • Cardiology
  • Nephrology
  • Cell Biology
  • Pathophysiology

Background:

  • Cardiorenal syndrome (CRS) is a complex condition where heart and kidney dysfunction exacerbate each other.
  • Understanding the intricate cell-to-cell communication between cardiac and renal systems is crucial for managing CRS.
  • Existing knowledge gaps hinder the development of effective therapeutic strategies for CRS.

Purpose of the Study:

  • To systematically review the pathophysiological mechanisms of CRS focusing on intercellular communication.
  • To analyze physiological and pathological communication pathways between cardiac and renal cells in CRS.
  • To propose novel therapeutic strategies targeting cell communication in CRS.

Main Methods:

  • Systematic literature review of cardiorenal syndrome mechanisms.
  • Analysis of intercellular communication pathways, including soluble factors and extracellular vesicles.
  • Examination of communication in different CRS subtypes and reinterpretation of current therapies.

Main Results:

  • Identified key intercellular communication pathways (soluble factors, extracellular vesicles) driving CRS.
  • Detailed unique communication features across various CRS subtypes.
  • Reinterpreted existing therapies through the lens of cell communication regulation.

Conclusions:

  • Intercellular communication is central to cardiorenal syndrome pathophysiology.
  • Targeting cell communication pathways, using strategies like extracellular vesicle therapy and miRNA delivery, shows therapeutic promise.
  • Further research into these communication mechanisms is essential for advancing CRS treatment.

Keywords:
Biological sciences

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