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Triphasic Adrenocorticotropic Hormone Dynamics During Immune Checkpoint Inhibitor Therapy in a Patient With Malignant

Natsumi Kuwata1, Natsuko Ohashi1, Maya Yonishi-Nakamura1,2

  • 1Department of Diabetes, Endocrinology and Nephrology, Shiga University of Medical Science, Otsu, Shiga, Japan.

AACE Endocrinology and Diabetes
|July 23, 2026
PubMed
Summary

Immune checkpoint inhibitor (ICI) therapy can cause a rare triphasic adrenocorticotropic hormone (ACTH) pattern, initially showing deficiency, then transient elevation, before permanent adrenal insufficiency. This highlights the need for careful monitoring in patients receiving ICI treatment.

Keywords:
adrenocorticotropic hormonehypophysitisimmune checkpoint inhibitorsecondary adrenal insufficiency

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