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ALK-Negative Systemic Anaplastic Large Cell Lymphoma with Cutaneous Involvement Initially Mimicking Primary Cutaneous

Huijing Wang1, Zongyang Li1, Shubo Zhuang1

  • 1Department of Cosmetic Dermatology, The First Hospital of Tsinghua University, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, People's Republic of China.

Clinical, Cosmetic and Investigational Dermatology
|July 23, 2026
PubMed
Summary

Anaplastic large cell lymphoma (ALCL) that is ALK-negative and presents with skin lesions is rare. Distinguishing systemic from primary cutaneous ALCL is crucial for prognosis and treatment, often requiring specific antigen testing.

Keywords:
ALK-negativeanaplastic large cell lymphomacase reportcutaneous involvementpoor prognosis

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